Glycoprotein of high molecular weight (2 chains each of 250 kD linked by disulphide bonds) that occurs in insoluble fibrillar form in extracellular matrix of animal tissues, and soluble in plasma, the latter previously known as cold-insoluble globulin. The various slightly different forms of fibronectin appear to be generated by tissue-specific differential splicing of fibronectin mRNA, transcribed from a single gene. Fibronectins have multiple domains that confer the ability to interact with many extracellular substances such as collagen, fibrin and heparin, and also with specific membrane receptors on responsive cells. Notable is the RGD domain recognized by integrins, and two repeats of the EGF-like domain. The Fibronectin Type III domain (FnIII), about 90 amino acids long, of which there are 15 - 17 per molecule, is a common motif in many cell surface proteins. Interaction of a cell\'s fibronectin receptors (members of the integrin family) with fibronectin adsorbed to a surface results in adhesion and spreading of the cell.

Dictionary of molecular biology. 2004.

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  • Fibronectin — 1 PDB rendering based on 1e88 …   Wikipedia

  • fibronectin — fibronectin. См. фибронектин. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • fibronectin — [fī΄brō nek′tin] n. an adhesive glycoprotein that helps destroy bacteria, etc. in the blood or that helps structure connective tissue …   English World dictionary

  • Fibronectin — Fibronektin (von lateinisch: fibra für „Faser“; nexus für „Verknüpfung“) ist ein extrazelluläres Glykoprotein, das in vielen physiologischen Abläufen, unter anderen in der Gewebsreparatur, der Embryogenese, der Hämostase sowie in der Migration… …   Deutsch Wikipedia

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  • Fibronectin type II domain — Pfam box Symbol = fn2 Name = width =250 caption =Collagen binding type II domain of seminal plasma protein PDC 109 Pfam= PF00040 InterPro= IPR000562 SMART= PROSITE = PDOC00022 SCOP = 1pdc TCDB = OPM family= 123 OPM protein= 1h8p… …   Wikipedia

  • fibronectin — noun Etymology: fibr + Latin nectere to tie, bind + English in Date: 1976 any of a group of glycoproteins of cell surfaces, blood plasma, and connective tissue that promote cellular adhesion and migration …   New Collegiate Dictionary

  • fibronectin — /fuy breuh nek tin/, n. Cell Biol. a fibrous protein that binds to collagen, fibrin, and other proteins and also to the cell membranes, functioning as an anchor and connector. [1975 80; FIBRO + L nect(ere) to bind, join together (see CONNECT,… …   Universalium

  • fibronectin — noun An adhesive blood glycoprotein that has several cellular functions …   Wiktionary

  • Fibronectin — Fi|b|ro|nec|tin [lat. fibra = Faser u. nectere = verknüpfen; ↑ in (3)] das; s, e; veraltetes Syn.: Opsonin: in tierischen Organismen weit verbreitete faserige dimere Glykoproteine vom MG 500 000, die an zellulären Haftprozessen maßgeblich… …   Universal-Lexikon

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